Summary
- Closed for EoI
- Profile Type
- Research & Development Request
- POD Reference
- RDRFR20240411008
- Term of Validity
- 11 April 2024 - 11 April 2025
- Company's Country
- France
- Type of partnership
- Research and development cooperation agreement
- Targeted Countries
- All countries
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General information
- Short Summary
- French start-up has developed proprietary bioproduction cell lines that precision control glycosylation, which is used to design antibody therapeutics with superior function. The first target is preventing patient resistance to treatments for autoimmune diseases. They are looking for partners for EIC Transition.
- Full Description
-
TNF-alpha inhibitors are front line treatments for autoimmune diseases, comprising a €45B annual market. To date, approximately 50% of patients develop resistance to the treatment. The company has developed proprietary tools for engineering of the glycans, sugar molecules, that are naturally found on the surface of a therapeutic drug. Sugar molecules are used to re-design TNF-alpha inhibitors creating a variant of the therapy that patients do not develop resistance to.
In a second work stream, the control of glycans is also being used for the development of antibody- drug conjugates (ADCs), with novel glycan sites enabling close control of the drug to antibody ratio, and a safer treatment for patients.
This proprietary glycan engineering strategy can be used to solve major challenges in antibody therapies, making them safer and more accessible to patients.
French start-up working in this field, who won several Innovation prizes, would like to find a partner eligible for EIC Transition, who can be a Coordinator. - Advantages and Innovations
- Glycan engineeirng of recombinant antibodies to enhance safety and efficacy of immunotherpaies. The company has developed proprietary bioproduction cell lines that precision control glycosylation, which is used to design antibody therapeutics with superior function. The first target is preventing patient resistance to treatments for autoimmune diseases.
- Stage of Development
- Under development
- Sustainable Development Goals
- Goal 3: Good Health and Well-being
- IPR description
-
Multiple types of partners envisaged, partner must have eligibility for the EIC Transition as of September 2024
- Partner with access to patient samples from autoimmune patients, enabling testing of therapeutics patient serum
- Partner who has developed proprietary technology in protein structural modelling, in order to model the behaviour of glycan engineered therapeutics with their target.
- Partner developing an antibody therapeutic that suffers from poor efficacy or high levels of toxicity in vivo.
- Partner developing a bi specific antibody.
- Partner with a linker technology for antibody drug conjugates.
- Partner with analytical techniques to examine glycosylated proteins (Mass spectrometery, DLS, other).
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Partner Sought
- Expected Role of a Partner
- To be eligible for EIC Transtion and to be Coordinator
- Type and Size of Partner
- R&D Institution
- University
- SME 11-49
- SME 50 - 249
- Type of partnership
- Research and development cooperation agreement
Call details
- Framework program
- Horizon Europe
- Call title and identifier
-
EIC Transition
- Submission and evaluation scheme
-
September 2024
- Anticipated project budget
-
2-3 mln Euros
- Coordinator required
-
Yes
- Deadline for EoI
- Deadline of the call
- Web link to the call
- https://eic.ec.europa.eu/eic-funding-opportunities/eic-transition_en
- Horizon Europe
Dissemination
- Market keywords
- 05005022 - Other clinical medicine
- 05006 - Anatomy, Pathology, Immunology, Physiology
- 05005014 - Oncology
- Targeted countries
- All countries