Summary
- Profile Type
- Research & Development Request
- POD Reference
- RDRTR20241014005
- Term of Validity
- 14 October 2024 - 14 October 2025
- Company's Country
- Turkey
- Type of partnership
- Research and development cooperation agreement
- Targeted Countries
- Italy
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General information
- Short Summary
- The Bioengineering Department at Yıldız Technical University is part of the Faculty of Chemical and Metallurgical Engineering. Since its inception, the department has been dedicated to providing cutting-edge education and research in the interdisciplinary fields of biology, chemistry, and engineering.
- Full Description
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We are proposing a research collaboration focused on developing an innovative solution that leverages exosome-releasing stent technology for the treatment of cardiovascular diseases. This project aims to combine the structural benefits of traditional stents with the regenerative and therapeutic properties of exosomes to create a more effective and targeted intervention for patients.
Project Goals:
The primary goal of this project is to design and optimize exosome-releasing stents that can promote vascular healing, reduce in-stent restenosis, and ultimately improve long-term clinical outcomes in patients undergoing cardiovascular interventions. By harnessing the therapeutic potential of exosomes, the project seeks to overcome the current limitations of bare metal and drug-eluting stents. - Advantages and Innovations
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Advantages of Exosome-Releasing Stents in Cardiovascular Therapy
Exosomes are currently being investigated in clinical studies for their immunomodulatory and tissue-regenerative properties in various conditions, including ischemic stroke and chronic kidney disease. Integrating exosomes into stent technology offers a unique opportunity to enhance their therapeutic potential in a localized and controlled manner, transforming their systemic benefits into a targeted cardiovascular intervention.
Key Advantages of Exosome-Releasing Stents:
1. Enhanced Vascular Healing: By combining the structural support of traditional stents with the regenerative properties of exosomes, this new stent technology aims to promote faster and more efficient vascular healing. Exosomes can modulate inflammation, promote endothelial regeneration, and enhance tissue repair at the stent site, potentially reducing complications associated with delayed healing.
2. Reduction of In-Stent Restenosis: In-stent restenosis (ISR), or the re-narrowing of the stented artery, is a significant limitation of traditional bare metal and even drug-eluting stents. Exosome-releasing stents have the potential to minimize ISR by providing a continuous, localized release of therapeutic agents that inhibit excessive tissue growth and fibrosis, maintaining arterial patency over the long term.
3. Minimized Systemic Side Effects: Unlike drug-eluting stents, which can cause systemic side effects due to the dispersal of pharmacological agents beyond the target site, exosome-releasing stents offer a more biocompatible solution. The localized delivery of exosomes ensures that therapeutic effects are concentrated at the stent site, minimizing the risk of off-target effects.
4. Overcoming Limitations of Current Technologies.
5. Support for Better Clinical Outcomes - Stage of Development
- Concept stage
- Sustainable Development Goals
- Goal 3: Good Health and Well-being
Partner Sought
- Expected Role of a Partner
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For this partnership, Yıldız Technical University’s Bioengineering Department seeks to establish a mutually beneficial collaboration that leverages the unique strengths and resources of both teams. Specifically, we expect:
1. Active Participation in Specific Project Phases: We aim for our international partners to take the lead or provide support in particular phases of the project, where their expertise can add substantial value.
2. Laboratory and Equipment Support: Given the advanced technological requirements of bioengineering research, we look forward to access to laboratory facilities and specialized equipment that may not be available locally.
3. Efficient Project Execution: A primary goal of the collaboration is to ensure the project progresses efficiently, with timely communication and coordinated efforts to achieve the defined milestones within the projected timeline. - Type and Size of Partner
- University
- Type of partnership
- Research and development cooperation agreement
Call details
- Framework program
- Access to finance
- Call title and identifier
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Italian The Ministry of Foreign Affairs and International Cooperation (MAECI) Bilateral Cooperation Call
- Coordinator required
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No
- Deadline for EoI
- Deadline of the call
- Access to finance
Dissemination
- Market keywords
- 05010003 - Patient rehabilitation & training
- 05001001 - Diagnostic services
- Targeted countries
- Italy