A novel hemoglobin complex for use as an oxygen carrier in the human blood was developed by a German research institute. At present the technology is owned by a consortium (consisting of an Austrian and a German small scale enterprise) which is further developing the hemoglobin complex. Both companies are specialized in the worldwide sourcing and development of biological raw materials.
1) State of the art:
Hemoglobin is an iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates which carries oxygen from the lungs to the rest of the body. Hemoglobin as an oxygen carrier is therefore essential to preserve organic tissue in various biotechnological and medical applications on living organisms (in vivo) and in test tubes (in vitro). Hemoglobin derived from human blood donations is a rare commodity and not available in sufficient amount. However, hemoglobin can also be isolated from an abundant and low cost source – bovine blood. There are many commercially available bovine hemoglobins but none is acceptable with regard to purity, safety or functionality. For this reason the currently available hemoglobin products cannot be used in applications or as a starting material for products that depend on the oxygen carrying capacity of hemoglobin. The market needs a new type of hemoglobin, suitable to work as a potent oxygen carrier.
2) Description of the technology:
The active hemoglobin complex is manufactured from calves' red blood cells sourced in Tyrol, Austria - a region free of most notifiable bovine diseases as well as of mad cow disease. It has been harvested from locally and organically raised animals with proven traceability and carefully monitored health records. The red blood cells are lysed and the hemoglobin is then obtained via centrifugation and filtration steps. The active hemoglobin can be used for the manufacturing of multi-hemoglobin complexes with advantageous properties.
3) Application Areas:
Beside the application as an oxygen carrier in the human body the hemoglobin complex can be used in many more application areas. Currently the hemoglobin complex is beeing further developed in the framework of a funded European project (€ 1 Mio). Scaling-up to reach industrial production levels is currently under development. Possible application areas are:
- Human erythrocytes replacement in cell culture media used during transport of organs for perfusion
- Active ingredient in wound bandages (especially for chronic wounds)
- Cell culture additive for better oxygenation
- Ingredient for biological coating of cell culture plastics
- Veterinary applications - contributing to joints healing of pet animals
- In treating hair loss
- In any other areas where an improved oxygen supply is required
4) Partner sought:
The Austrian company is looking for companies and research institutes with a need for specific oxygen carriers. In this sense a technical cooperation agreement is sought with no need for financial input from cooperation partners.
The Austrian company would like to get in contact with any kind of company that is interested in the existing oxygen carrier. In this sense a commercial agreement with technical assistance is sought. In the case of a technical distribution partner, a license agreement is sought.