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Biocollection of tissues and associated data focused on metabolic disorders offered under licence agreements

Country of origin:
Country: 
FRANCE
Opportunity:
External Id: 
BOFR20200421001
Published
05/05/2020
Last update
06/05/2020
Expiration date
07/05/2021

Keywords

Partner keyword: 
Medical Research
Stem cells and biobanks
Other clinical medicine
Other human health activities
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Summary

Summary: 
A French Technology Transfer Office offers to pharmaceutical companies, diagnostics manufacturers or biomarkers researchers a licence agreement for the access to a biobank focused on metabolic disorders. This biobank includes human samples and associated data to allow the discovery and the preclinical validation of biomarkers and therapeutic targets associated with the onset of metabolic troubles.

Description

Description: 

Overweight affects 39% and obesity 13% of the world adult population, together representing 2,5 billion people affected by weight problems in the world. The prevalence of obesity has tripled over the past 40 years. To date, the therapeutic options for obesity, diabetes but more generally metabolism troubles (including NASH/ non-alcoholic steato-hepatitis, NAFLD / non-alcoholic fatty liver disease, etc.) are limited, and unfortunately the pipeline isn’t promising enough.
A French Technology Transfer Office (TTO) is acting on behalf a major university hospital and a university which created a biobank focused on metabolic disorders to provide to researchers samples as close as possible to the human disease, which means "human relevant" translational tools. Its goal is to help the development of therapeutic active ingredients and biomarkers to tackle metabolic disorders.
The collection comes from a project aiming to set up a collection of human tissues and associated data from patients presenting obesity, with or without metabolic abnormalities; its objective is the identification and validation of biomarkers associated with the onset of Diabete type 2 and its aggravation.
The biobank is composed of samples collected in morbidly obese patients with different metabolic status such as: insulin-sensitivity, insulin-resistance, and type 2 diabetes. For each patient, the biobank includes biopsies from liver, muscle, adipose tissue, and epiploic artery. Plasma, serum and extracted DNA are also available. In addition to samples, associated data were collected for each patient such as clinical and biological data, but also eating behaviour, physical activities, family history, treatments, etc.
Comorbidities of diabetes and obesity are also available in the biobank. This way, the biobank is also able to provide samples and information focusing on NASH (non-alcoholic steato-hepatitis), NAFLD (non-alcoholic fatty liver disease), hepatic fibrosis, diabetic nephropathy, cardiovascular diseases, etc.

The French TTO is looking for a licensing agreement with pharmaceutical companies, diagnostic manufacturers or biomarker discovery companies involved in metabolic disorders and willing to access to the biobank samples under material transfer agreements (MTA).

Advantages & innovations

Cooperation plus value: 
Complete tissue collection and a wide variety of data: the combination of biopsies, blood derivatives and patient data allows to study new biomarkers, therapeutic targets, links between lifestyle habits and phenotypes, etc. Stratification: The cohort that lead to the biobank is highly characterized and specific – this allows to study populations and sub-populations of patients with a personalised medicine approach. Quality management system: Built with strict requirements and relying on various quality controls (ISO 9001-2015, NFS-96 900).

Stage of development

Cooperation stage dev stage: 
Already on the market

Partner sought

Cooperation area: 
The biobank offers access to samples and data through a material transfer agreement (MTA) to: - Pharmaceutical companies involved in the early development (drug discovery, preclinical, phase 1) of therapies for metabolic disorders (obesity, type 2 diabetes, NASH, NAFL). - Diagnostic manufacturers developing diagnostic tests and companion tests for metabolic disorders (obesity, type 2 diabetes, NASH, NAFL) - Industrial companies specialising in biomarker discovery and the development of diagnostic tests.