Enterprise Europe Network

Bioinspired adhesive membranes for tissue regeneration

Country of origin:
Country: 
SPAIN
Opportunity:
External Id: 
TOES20211006001
Published
06/10/2021
Last update
14/10/2021
Expiration date
15/10/2022

Keywords

Partner keyword: 
Biobased materials
Pharmaceutical Products / Drugs
Cellular and Molecular Biology
Micro- and Nanotechnology related to Biological sciences
Cellular and Molecular Biology
Micro- and Nanotechnology related to Biological sciences
Internal medicine
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Summary

Summary: 
Spanish nanoscience and nanotechnology research centre has developed an innovative, biocompatible, flexible and modifiable catechol-based membrane for tissue regenerative applications. It shows adhesive properties in water environments, and its chemical properties are tuneable by functionalization with different (bio)molecules. Membrane thickness and size can be controlled by reaction conditions, easy to scale-up. Partners interested in research collaborations or license agreements are sought

Description

Description: 

The Catalan (Spanish) research centre is a non-profit global leader organization, focused on the newly-discovered physical and chemical properties that arise from the behaviour of matter at the nanoscale.

The rising prevalence of chronic diseases, genetic disorders, and cancer increases generates higher demands of new medical products to face regeneration of damaged tissues. Currently the are no specific therapies based on tissue regeneration. This is especially relevant in osteoarthritis, where palliative and chirurgic articulation substitutions solutions are applied, and chronic wounds or burn trauma cases, where skin grafts with several drawbacks associated are applied (such as lack of adherence and necrosis or lack of sensory capacity of the resulting skin). Market alternatives of the product are hydrogels, but they are generally fragile systems that require to be coated with other materials for making them biocompatible or adhesive, multi-steps method fabrication and high production costs.

The membranes presented are obtained by copolymerisation between catechol-derivates and amino-based molecules. They are flexible and show adhesive properties in water environments. The methodology for fabricating these bioinspired membranes is performed using commercial compounds and under mild conditions, a straightforward procedure easily scalable, as the membranes are formed in the air-water interface without using neither a multi-step approach nor harmful solvents. Once the membranes are formed, they can be properly isolated, handled and transferred to the final tissue or substrate. The thickness of the films can be controlled over time, achieving sizes from tens of nanometers to a few micrometers. The tuneability of the reactivity of the membranes allows for in situ and post-functionalization, making possible the inclusion of molecules and biomolecules of interest. Worth to mention, the membranes presented different topography depending on the side, allowing them to be functionalized with different (bio)molecules on each side in addition to directly impact in their biological behaviour.

The membranes have three main applications:
• Research and development in biotechnology: the membrane can be used in research experimental and clinical development laboratories, in the biotechnology and nanotechnology sectors.
• Veterinary and medical applications: adhesives, implants and dressings.
• Cell regenerative therapies

The research centre is looking for companies in the pharma and medical devices sectors, interested in leading proof of concept studies to validate the technology for specific applications under a research collaboration or willing to bring the technology onto the market under a license agreement.

Advantages & innovations

Cooperation plus value: 
- Adhesion in humid and underwater conditions - Easy to scale-up - Functionalization with molecules and biomolecules - Advanced flexibility, stability, and biocompatibility - Cells can be seeded and grown directly on the membrane - Easy to manipulate without tiring - Resists stretching, bending and elongating motions - Exhibit different topographies on each sides, conferring different chemical and growth properties

Stage of development

Cooperation stage dev stage: 
Prototype available for demonstration

Partner sought

Cooperation area: 
The research centre is looking for companies from the pharma, medical devices, tissue regenerative therapies and research and development in biotechnology sectors interested in either licensing the patent (under a license agreement) or leading proof of concept studies to validate the technology for specific applications (under a research cooperation agreement).

Type and size

Cooperation task: 
SME 11-50,SME <10,>500 MNE,251-500,SME 51-250,>500

solution_image.jpg

Figure. Catechol based membranes for tissue regeneration