Enterprise Europe Network

Coxsackievirus variant for treatment of cancer

Country of origin:
Country: 
GERMANY
Opportunity:
External Id: 
TODE20200326001
Published
26/03/2020
Last update
02/04/2020
Expiration date
03/04/2021

Keywords

Partner keyword: 
Cytology, Cancerology, Oncology
Cellular and Molecular Biology
Other therapeutic (including defibrillators)
Oncology
Anatomy, Pathology, Immunology, Physiology
Research and experimental development on biotechnology
Other human health activities
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Summary

Summary: 
A Berlin-based university has developed a modified variant of Coxsackievirus B3 that offers a new safe method of treatment of cancer. The institute is interested in a cooperation in the framework of a license or a research cooperation agreement.

Description

Description: 

Immunotherapies using oncolytic viruses - viruses that preferentially infect and kill cancer cells - offer a novel specific possibility of treating malignant tumors. Coxsackievirus B3 (CVB3) as an oncolytic RNA-virus possesses particular benefits including a short replication cycle, the generation of an abundant number of virus progeny, a strong cytolytic activity - cells bursting due to an osmotic imbalance -, and the introduction of robust anti-cancer immune responses. However, it was shown that the wild type CVB3 (Nancy strain) can cause severe inflammations and infections in humans and therefore an application as a safe oncolytic virus is questionable.
The invention presented here uses a modified variant of the CVB3 wild type, isolated after serial passaging in human fetal primary fibroblast cells. The new CVB3 – variant (PD-0) shows strong lytic effectiveness in tumor cells and inhibits the tumor growing in vivo without causing side effects. The altered amino acid sequence, positively influencing the absorption of the virus into tumor cells, seems most likely to be responsible for this. Thus, the invention offers a new, safe method of treatment for cancer. Furthermore, PD 0 represents a basis for the development of novel PD-0-virus variants with further enhanced properties. This opens up the possibility to adapt the used virus more specifically to the tumors to be treated, thus enhancing the efficiency of the treatment even more.

The university is interested in a cooperation in the framework of a license agreement or a research cooperation agreement. A future licensee would have the authorization to use the modified variant of the virus in return for a fee or a share of royalties. The client would also agree to a research cooperation agreement that aims at the joint development of an approved immunotherapeutic method for the treatment of cancer.

Advantages & innovations

Cooperation plus value: 
- Efficient tumor destruction - Non-lethal and treatable side effects - Sipmlified production - Basis for additional variants - Treatment customizable for the tumor to be treated

Stage of development

Cooperation stage dev stage: 
Prototype available for demonstration

Partner sought

Cooperation area: 
The university is looking for partners from the biotechnology or pharma industry or biological research for a license or a research cooperation agreement. In the framework of a license agreement partners like industry, SMEs or academic would be authorized to use the licensed Coxsackievirus in the process of the further development of a method in the field of oncovirotherapy. In a research cooperation agreement the partner could be industry, a SME or a university to further develop the used virus more specifically to adapt it to the tumors to be treated.