Inflammatory events are the principle cause of rapid extrinsic and intrinsic skin aging. Inflammatory events in the skin lead to a reduction in collagen gene activity, alter proliferation rates of cells in all skin layers, cause a thinning of the epidermis, a flattening of the dermo-epidermal junction, and an increase in irregular pigment production. It is important, in the cosmetic sector, to find natural compounds that inhibit the production of inflammatory molecules in the skin and develop topical products to avoid inflammation and retard or even reverse the skin aging process.
A Spanish research group specialized in biochemistry has developed an innovative topical treatment from 5-dodecanolida involved in inflammatory response. It reduces considerably skin inflammation related to bacterial infections and shows no toxicity levels.
The formulations of the present invention may be commercially available or obtained by chemical synthesis or through an extraction and purification process from pig lard from which researchers have developed principle agents. These compounds with anti-inflammatory properties are generated physiologically allowing the effective modulation of inflammatory processes and the reduction of side effects. Low concentrations are needed to reduce anti-inflammatory action that reveals their anti-inflammation power. The administration route is variable and the composition can change depending on it. However, the topical administration is preferred as an ointment or cream.
Anti-inflammatory properties of active ingredients have been tested through in-vitro and in-vivo experiments with laboratory animals and human immune cells. A toxicity study on 5- dodecanolide has been also conducted. It has demonstrated that in comparison with other commercial anti-inflammatory products, the compound shows no toxicity.
European cosmetic companies capable to conduct in-vivo and clinical trials necessary to continue developing a cosmetic product are being sought for a license agreement.