The organization is a Spanish biotechnological private non-profit research institute, founded in 1993, whose main activities are related to molecular biology and microbial biotechnology. The institution keeps close links with industrial research and innovation. The team covers several techniques and counts with a long experience in scientific research in European funded projects.
The Institute’s research group of the molecular microbiology of Streptomyces is seeking partners to build collaborative projects. For this, the group would provide expertise in the following techniques: a) microbial culture techniques, including fermentation cultures for production of secondary metabolites and high pressure liquid chromatography (HPLC)-based quantification of products; b) gene cloning and genetic engineering techniques, including species that are difficult to modify, c) protein expression and purification, d) transcriptional regulation studies, including electrophoretic-mobility assays, footprinting assays, and bioinformatics of binding sites; e) transcriptomic analysis (both microarray and ribonucleic acid sequencing (RNA-seq); f) 2-D proteomics and mass spectrometry, g) bioinformatics, including genome sequencing.
The specialized equipment for the transcriptomic studies includes homogenization/disruptors cell systems for nucleic acid or protein extraction, RNA analyses, real-time polymerase chain reaction (PCR) instrument for gene expression analysis and the platform for microarray transcriptomic. Workstations are available for bioinformatics.
The specialized equipment for proteomics studies includes a chromatography system for protein purification, a bidimensional gel electrophoresis system, fluorescent gel and membrane scanners, and a matrix-assisted laser desorption/ionization of time of flight (MALDI TOF/TOF) mass spectrometer.
The institute is also equipped with a pilot plant hosting, among others, a battery of four 5-liter fermenters, as well as HPLC apparatus to analyze secondary metabolites production.
The research institute is looking for industrial and academic partners from pharma services agreements based on the know-how of the center. It is also interested in collaboration in order to prepare proposals for European projects as Horizon 2020 or Innovative Medicines Initiative (IMI) calls.