Ultra-flexible passive microelectrode array (MEA) has been designed to allow an easy adaptation to the brain surface. The MEA is composed of 32 single ended channels for the neuronal signal recording and several stimulation electrodes (at least 4) for the neural stimulation. The MEA is coupled with an electronic interface able to amplify, filter and digitalize the data specifically designed to match the MEA specifications. The electronics is able to simultaneously acquire the signal captured by the whole set of MEA electrodes and moreover, apply independent stimulations on the stimulation electrodes.
The whole system represents a state-of-the-art tool for low-power biosignals recording and provides enhanced performance if compared to commercially available tools. One of its best characteristics is the versatility, indeed, it could be used as a fully integrated system for the electroencephalographic recording or thanks to the directly connection to a computer by USB port and a totally customizable software can be used to perform a plethora of other applications as:
• miniaturized multi-channel headstages for neural or electrocorticography recording
• low-power wireless headstages or backpacks for electrophysiology experiments
• recording spikes and/or local field potentials (LFPs) from microelectrodes
• in vitro recording systems “Smart Petri dish”
• portable electrocardiogram or electromyography monitoring systems
• advanced prosthetic limb controller front-ends
Moreover, taking advantage of the stimulation channels an investigation on algorithms of closed loop control of the neuronal activity could be implemented.
The group is looking for: 1) a technical partner that can provide an implantable water-proof titanium case with the following dimensions 3x1x0.5 cm; 2) financial partners interested in financing the recording and stimulation functions of the implantable electronic card; 3) scientific/academic partners interested in developing methods and technologies to record electrophysiological signals from the cortical, peripheral nerves or spinal cord.