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German research centre offers methods and know-how in the fields of life sciences and cryogenics under services agreement

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Partner keyword: 
Biobased materials
Analytical Chemistry
Analyses / Test Facilities and Methods
Chemical material testing
Biochemistry / Biophysics
Cellular and Molecular Biology
In vitro Testing, Trials
Engineering services
Other transportation support activities
Technical testing and analysis
Research and experimental development on biotechnology


The German client solves various problems in fields of cryobiology, cryogenics and refrigeration. They are specialized e.g. in development of cryoprotocols, image analysis and safety tests of materials/packaging under cryogenic storage conditions for bio- and cryobanking applications, tightness assessment of biobanking tubes and characterization of particles in suspension by rheological measurement. Partners are sought in terms of services agreement or subcontracting.



The German Centre is part of an independent and free research institution that has the legal status of a non-profit limited liability company. Its portfolio comprises, e.g. process and product development, manufacturing, prototyping and scientific technical services including experimental testing and analyses. The enormous expertise is bundled at the Centre.

One of the main working fields is the development of technology and hardware for cold applications in several fields of tissue engineering, cryobiology, cryomedicine and pharmaceutical freezing as well as testing and analytics. The client offers large experiences in processing and manufacturing 3-D biomaterials with customized structures, pore sizes and cell specific additives on basis of biopolymers, e.g. hyaluronic acid and collagen.

Due to rheological measurement in a wide temperature range, a complete characterization of the dispersions, e.g. pastes, gels and polymers, is possible. The determination of the yield point or non-Newtonian behavior from measured flow curves, the temperature depending viscosity or thixotropic behavior could be determined. The stability of the dispersion over time or the linear viscoelastic range could be determined with oscillatory measurement.

A second part is the determination of dispersed (solid) particles in solution by using different measurement ranges and flow through cuvettes. The physical measurable sizes of particles could be adapted to their general form, e.g. diameter or perimeter of a circle with an equivalent area for approximately spherical particles, fibre length for fibrous material or Feret diameter for irregular shapes. To describe the particles, the shape can be determined, e.g. aspect ratio, convexity or sphericity. For elongated particles like fibres, length and straightness can be determined. For every imaged particle its parameters can be described separate.

With this features it is possible to detect single particles which don’t match the requirements, e.g. in a production batch, or to prove an evidence for agglomeration.

Furthermore, the Centre is developing histological methods for biological and technical materials. The process steps can be customized in close agreement with the client to get the best results. The Centre offers different methods of dewatering, penetration and embedding, e.g. paraffin or liquid plastic embedding, and modern cutting techniques down to 5 µm. With a wide range of staining techniques, depending on material or cell population, and optical as well as fluorescence microscopic imaging nearly every material can be evaluated.

The broad expertise of the German client ranges from HE-stained oral mucosa over Masson-Goldner stained bone tissue to fluorescence dying methods and to damage analysis of synthetic polymers and preparation of difficult materials.

The examination of product and transport safety of packaging materials under cryogenic conditions is another working field. With innovative methods, the quantity of carbon dioxide penetrating the packaging material or the seal can be identified as well as the tightness in contact with liquid nitrogen under storage conditions.

Cooperation in terms of a services agreements:
The client is looking for partners to solve their:
- Technical challenges and measurements
- Problems in the characterization
- Problems in production of dispersions
- Problems with tightness/ transport safety of packaging materials, which are used for storage under cryogenic environment.
- Problems with successful cryopreservation of tissues or of replacement models for animal testing.

Cooperation in terms of subcontracting:
The Centre offers also its expertise as project partner or subcontractor in public funded research or industrial research.

Advantages & innovations

Cooperation plus value: 
The client owns a wide range of analytical equipment and technical knowhow. A variety of staff with different knowledge consisting of biologists, physicians, biochemists and engineers as wells as a development and construction team provides solutions for many problems in the field of analytics, low temperature physics and biology for applications in life sciences. This bundled experience allows a quick response and flexibility according to customers’ needs and meets the requirements of different DIN and ISO standards. Furthermore, the Centre offers special knowhow for rheological characterization and particle imaging of dispersions in the fields of quality control, production support and R&D cooperation. The examination of packaging materials for storage of chemical or biological probes under cryogenic conditions is another specialist field. Other parts of the services are the proof of tightness against penetrating gasses, e.g. nitrogen or carbon dioxide, as well as important transport safety tests for shipping of any liquid goods by aircraft according to IATA or ADR regulations.

Technical Specification or Expertise Sought

Cooperation sought: 
Test procedures for tubes etc. are under continuous development. Special test stands are ready to use for various tightness investigations. Prototypes of racks for an enhanced freezing process for tissues etc. are available.

Stage of development

Cooperation stage dev stage: 
Already on the market

Partner sought

Cooperation area: 
The German research centre wants to provide its special services in the fields of cryogenics, cryobiology and life sciences. Furthermore, the client is specialized in process and product development, manufacturing, prototyping and scientific technical services including experimental testing and analyses. Now they are looking for cooperation partners from industry, public and private research institutes, federal and regional scientific offices, who are interested in removing common barriers in the mentioned fields to conclude a services agreement. The German client is also interested in cooperation as a project partner or subcontractor for public funded research or industrial research projects.

Type and size

Cooperation task: 
SME 11-50,University,Inventor,R&D Institution,SME <10,>500 MNE,251-500,SME 51-250,>500