Phospholipids and fatty acids are the main building blocks of biological membranes and present a great number of biological applications. Currently, in the fields of cosmetics, dermatology and pharmacy, a growing interest exists in the development of hydrogels that mimic and respect biological systems. In this sense, hydrogels formed by lipids may offer numerous competitive advantages. However, the available lipid hydrogels are only formed either at very high lipid concentrations (> 50%) or in diluted conditions in which the system requires the presence of surfactants or gelling agents. These conditions often induce problems of biocompatibility and sensitization.
Presented here is a new nanostructured lipid gel formed by intercalated vesicles and extended lamellae. It is constituted exclusively by combination of phospholipids and fatty acids (3-10%) with a very high content of water present (97-93%).
The composition, exclusively made of lipids, ensures high biocompatibility and its rheological behaviour enables its use in medical applications, especially at topical, mucosal and ocular level.
Ex-vivo studies, using porcine skin, have been carried out to corroborate permeation of actives through the skin and follicles and its wound healing effect. This gel has also been proved to be non-irritating in ocular formulations.
The research group, with a broad experience in lipid systems for drug delivery and skin treatment, is searching for pharmaceutical and cosmetic companies interested in the use of these hydrogels. Companies should carry out, either by themselves or through research collaboration with our organization, studies to develop specific applications adapted to their interests.