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Italian research group offers chemotherapy, a drug monitoring system for Imatinib and looking for financial agreement

Country of origin:
Country: 
ITALY
Opportunity:
External Id: 
TOIT20200713001
Published
13/07/2020
Last update
15/07/2020
Expiration date
16/07/2021

Keywords

Partner keyword: 
Cytology, Cancerology, Oncology
Medical Technology / Biomedical Engineering
Pharmaceutical Products / Drugs
Biochemistry / Biophysics
Diagnostic services
Diagnostic equipment
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Summary

Summary: 
An Italian research group has developed an electrochemical method to measure the concentration of the anti-cancer drug Imatinib in patient's plasma and then to establish the optimal dose, with an on-site test readable in real time. They are looking for financial agreement to facilitate the production of the prototype.

Description

Description: 

The effectiveness of many anticancer drugs varies greatly from patient to patient, with risks of incorrect dosages and adverse side effects. The invention provides for the first time an electrochemical method to measure the concentration of the drug Imatinib, an anticancer drug used in particular for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. The therapeutic drug monitoring (TDM) greatly improves the effectiveness of the cancer treatment and helps to personalize the doses and to limit side effects. Quick procedures are therefore essential. The patented electrochemical method provides a simple, fast and cost-effective protocol for the measurement of Imatinib concentration through plasma collection; said method is suitable for the manufacturing of a device, that will make the test results readily and easily accessible at the patient's bed (point-of-care), avoiding long times required by specialized analysis. The method involves the selective extraction of the drug on a liquid-liquid extraction column and a following measurement of its concentration using an electrochemical technique, in particular adsorptive stripping voltammetry.
The system is under developement / lab tested and they are looking for partnerships with industry or investors in order to realize a prototype and go to market.

Advantages & innovations

Cooperation plus value: 
Simple protocol to be performed also by non-specialized personnel; rapid and accurate diagnosis on site; minimum amount of plasma required; results in real time; determination of drug concentration and therefore of treatment effectiveness for a timely adjustment of individual dosage.

Stage of development

Cooperation stage dev stage: 
Under development/lab tested

Partner sought

Cooperation area: 
They are looking for a financial partner to facilitate and speed up the production of the prototipe.