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Microorganisms for the degradation of Bisphenol (BPA) for the production of probiotic foods and/or plant probiotics for its addition to phytosanitary compositions

Country of origin:
Country: 
SPAIN
Opportunity:
External Id: 
TOES20210616001
Published
16/06/2021
Last update
25/06/2021
Expiration date
26/06/2022

Keywords

Partner keyword: 
Pharmaceutical Products / Drugs
Enzyme Technology
Microbiology
Toxicology
Food and feed ingredients
Food & feed ingredients
Plant health
Health food
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Summary

Summary: 
A Spanish university has developed a technology using bacteria which are capable of degradation and removal of Bisphenol A (BPA) a chemical that is present in many commercial products, including food containers and hygiene products.The university is looking for partners in order to licence the patented technology.

Description

Description: 

Bisphenol A (BPA) is a chemical compound that is used since the 1950s to produce strong and resilient plastics. These days, BPA-containing plastics are commonly used in food containers, baby bottles, and other items. The pervasiveness of this substance, along with its analogues and derivatives, has been linked to the development of endocrine and metabolic diseases, such as obesity, diabetes, metabolic syndrome, fatty liver disease, hyperactivity disorders or cancer. Due to its estrogen-like shape, BPA can bind to estrogen receptors and influence bodily processes, such as growth, cell repair, fetal development, energy levels, and reproduction. In addition, BPA may also interact with other hormone receptors, such as those for the thyroid, thus altering their function.

Researchers at the University of Granada have identified a microorganism (Bacillus sp. strain from the human gut microbiota), with the ability of degradation and removal of Bisphenol A. Whole Genome Sequence analysis of these bacteria, with inulinase activity, revealed the presence of a complete enzymatic, molecular and genetic arsenal, specific for endocrine disruptors degradation, such as BPA. They are capable of tolerating and metabolizing it, while using it as a carbon source.

This activity evidences this strain’s potential, either alone or in combination with others, for the production of probiotic foods and/or plant probiotics for its addition to phytosanitary compositions, taking advantage of the ability to modulate those xenobiotics, relieving its endocrine pathogenesis and/or its use in bioremediation.

The university is looking for partners in order to licence the patented technology.

Advantages & innovations

Cooperation plus value: 
- Multitude of applications. Bisphenol A degradation can be useful in a wide range of areas: o Nutrition. Development of functional foods for human or veterinary use. o Human health. Modulation of endocrine pathogenesis caused by BPA. o Agriculture. Development of phytosanitary compositions for plants. o Bioremediation. Focused on the removal of contaminants from water. - High efficiency: Bacillus sp. AM1 strain can remove 84% of BPA in 72 hours. - Safe microorganisms: The bacteria have been isolated from the human microbiota, so it will very possibly meet the safety criteria and be granted QPS status (Qualified Presumption of Safety).

Stage of development

Cooperation stage dev stage: 
Under development/lab tested

Partner sought

Cooperation area: 
The university is looking for partners from companies related to probiotic products, such as functional foods, or water treatment using enzymes or microorganisms.

Type and size

Cooperation task: 
SME 11-50,SME <10,>500 MNE,251-500,SME 51-250,>500

1_bpa_gene_encoding_enzyme_pathways.png

Gene encoding enzyme pathways

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Bacillus for neutralizing obesogenic effects