The Spanish research group has a wide experience in structural health monitoring and instrumentation of civil engineering structures and belongs to a medium-sized Spanish university founded in 1994, housing others 76 research groups more. The university has been very active in several European reseach and innovation programmes (H2020 and previous FPs, LIFE, Justice, ERASMUS+, Interreg, COST, LLP, IEE, Research Fund for Coal and Steel, D. G. for Competition Policy and Strategy, Science for Peace and Security Programme-OTAN…) with over 50 European projects; with the role of coordinator in 22 projects and over 8.4 M€ overall EU funding received. Currently, this university participates in 26 on-going projects (in 12 of them as coordinator) in 8 different EU programmes with an average of 1.7 M€ of EU funding in the last 4 years.
This North Spanish university has a long history in the development of new technologies. In addition, it aims to promote the connection between the university and business environment, promoting a more entrepreneurial university in its task of creating and transferring technology.
In the case of Iridium(III) complexes described have characteristics that differentiate them from known complexes. They show significant activity as photocatalysts or photosensitizers, absorbing energy from light and transferring it to oxygen to form reactive species that act as oxidants. Furthermore, the synthesis of the Iridium III) complexes is carried out under mild conditions and shows good yields.
Cationic Iridium(III) complexes of formula (M+)nXn- are characterized in that the Iridium atom is coordinated to two 2-phenylpyridinate ligands, by the nitrogen atom of the pyridine ring and one of the carbon atoms of the phenyl group; and to a ligand derived from β -carboline, via two nitrogen atoms. These complexes can be used as photocatalysts in organic synthesis or as photosensitizers.
In organic synthesis, these allow the regioselective thiocyanation of indoles to be carried out, in the C-3 position, in a one-pot process and from the corresponding indolines. First, there is a dehydrogenation of indoline and, subsequently, thiocyanation. Both reaction steps involve the use of oxygen in the presence of light and the use of Iridium(III) complexes as photocatalysts.
Potential applications of the new Ir(III) complexes are as follow:
- Photooxidation reactions in organic synthesis.
- Use as photocatalysts in thiocyanation reactions of indoles.
- Photosensitizer in photodynamic therapy in the treatment of cancer.
- Preparation of a drug for the treatment of cancer, in combination with radiotherapy, that is, where said drug is administered together with, or before, the administration of radiotherapy.
The type of associations sought by the researcher group are license or manufacturing agreement, and/or research cooperation agreement, with other R&D institituos or industry of chemistry or pharmaceutical sectors. Additionally, further development, testing new applications and/or adaptation to specific needs are offered to the potential partner.