A novel approach in which activated gold particles are used has been invented for formation of material with reduced toxicity and increased antibacterial activity. Gold nanoparticles, which are naturally inert for living organisms and ineffective against bacteria, are combined with ceramics and carefully selected organic biomolecules into composites with very high antibacterial activity. This material has been activated for antibacterial activity in such a manner that it is twice as efficient as compared to silver. At the same time it possesses very high in vitro biocompatibility which is a significant improvement in comparison with previously used materials. This invention is concerned with:
The functionalized ceramic/metallic (apatite structured material/gold) composite is formed of apatite plate-like, micrometer-sized particles as a carrier of spherical gold nanoparticles attached to their surface. Such gold nanoparticles are functionalized by natural-sourced amino acids essential for the human organism (glycine, histidine or arginine). The material is active against bacteria and entirely nontoxic to humans.
2. Synthesis procedure:
A sonochemical method has been developed for the synthesis of a functionalized ceramic/metallic composite. The procedure includes the use of ultrasonically dispersed apatite within an aqueous solution of gold-precursor. The reduction of the gold is initiated by amino acids and supported by the radicals formed after the sonication of a low concentration of isopropanol. The developed method is easy, fast, and does not use any toxic substances. Method also shows good possibilities for scale-up.
The Slovenian research institute is looking for industrial partners – manufacturers of products that need to have antibacterial properties such as implants in orthopaedics, dentistry, plastic surgery, first-aid material, cosmetics for hygiene (tooth pastes, mouthwash liquid, soaps, shower gels, etc.), paints etc. Important market application of antibacterial products are filters (component of face-masks, respirators or antibacterial layer inside air-conditioners for elimination of bacteria from air in hospitals, laboratories and enclosed public and domestic places, antibacterial filters inside refrigerators, washing machines, vacuum cleaners, etc.). Food industry is also significant area for implementation of green and healthy materials that are able to prevent development of bacteria. These components are applicable for coating of the packaging as well as for chewing gums with antibacterial activity for prevention of caries and other dental and oral infections and as dietary supplement.
The industrial partners are expected to enter licensing agreements with the aim of implementing the antibacterial material into the existing or emerging products. If the industrial partner finds that complementarity between their products and the offered material needs to be improved, the Slovenian research institute is willing to enter into research cooperation agreement as well.