Enterprise Europe Network

Novel bioadhesive for wound closure in animals or humans

Country of origin:
External Id: 
Last update
Expiration date


Partner keyword: 
Biobased materials
Surgical instrumentation and equipment
Emergency medicine
Other clinical medicine
Disposable products
Animal health
Other research and experimental development on natural sciences and engineering
Tertiary education


A Spanish university has developed a new biomaterial for use as an adhesive or tissue sealant applicable to both animals and humans. This invention has optimal properties such as biocompatibility with living tissues, high adhesive capacity, is adaptable to the tissue of the wound, has an absence of toxicity and tissue regeneration properties. The research group is looking for companies interested in commercially exploiting this technology through license or technical cooperation agreements.



Medical and veterinary adhesives and sealants are used in clinics and surgery as an alternative to other wound closure methods such as sutures or staples. In addition, they allow wounds to stop bleeding quickly in accidents and health emergencies, shorten the healing time and minimize or completely eliminate scarring.

Currently, adhesives are based on synthetic or natural polymers. However, both kinds of polymers, present serious disadvantages. To overcome them, a Spanish research group has developed a new biomaterial for use as an adhesive or tissue sealant that has excellent properties such as biocompatibility with living tissues, high adhesive capacity, is adaptable to the tissue that is being bonded, has an absence of toxicity and tissue regeneration properties.

The polymeric biomaterial is preferably generated in situ on the wound to be closed, adding simultaneously on it a solution of a dendron (see Figure 1) and a cyanoacrylate adhesive. Then, in contact with body water or blood, the polymerization reaction of the cyanoacrylate is produced which chemically anchors dendron molecules, forming the corresponding polymeric biomaterial on the wound to be closed or sealed. The polymeric biomaterial hardens (curing process) as the polymerization reaction takes place, leaving a thin layer of it on the wound or tissue.

This invention can be very useful in the treatment and care of wounds, in the closing of wounds by accident, in medical, cosmetic and plastic surgeries, repair broken nails, etc.

The research group is looking for biomedical/pharmaceutical and veterinary companies interested in acquiring this technology for commercial exploitation through licensing agreements.

The research group would be also interested in establishing technical cooperation agreements to further develop this technology, to find new applications or to adapt it to the company’s needs. The University would offer its support based on their know-how; while, the partner sought would provide its expertise to help improve this invention. The university would offer this partner a preferential option to acquire this technology in exclusivity.

Advantages & innovations

Cooperation plus value: 
The formation of adhesive materials by cyanoacrylate polymerization to form a solid layer is already known. In this case, the innovation is in the simultaneous addition of both cyanoacrylate adhesive and bifunctional dendrons to the wound. The final result will be the formation of a new biomaterial with important advantages: • Increased polymerization rate in contact with a biological environment. • Reduction of the exothermic reaction during the polymerization process of cyanoacrylates in the presence of water or blood, avoiding risks of tissue death (e.g. necrosis). • Improvement of the reactivity of the cyanoacrylate monomers by eliminating secondary toxic compounds from their polymerization that do not normally react with them. • Increase in the flexibility of the polymerized adhesives, which avoids their premature detachment as time passes since their application. • It allows aesthetic improvements (i.e. absence of scars) due to better tissue integration and re-sorption of the polymerized adhesive. • It does not generate toxic by-products.

Stage of development

Cooperation stage dev stage: 
Under development/lab tested

Partner sought

Cooperation area: 
- Type of partner sought: companies - Specific area of activity of the partner: Biomedical / pharmaceutical / veterinary - Task to be performed: * In the license agreement: to buy a license for the technology, in order to further develop it to the industrial scale and to introduce it into the market. * In the technical cooperation agreement: to provide their expertise in order to collaborate with the scientists on further development and improvements of the technology. The company should identify technical and/or market requirements as well as the client´s needs in order to carry out further technical development so that the market readiness will be increased and the technology could be commercially exploited.

Type and size

Cooperation task: 
SME 11-50,SME <10,>500 MNE,251-500,SME 51-250,>500