This research networking center gathers some of the main Spanish research groups in biomedicine, located in more than 100 institutions like universities, hospitals, and technological centers distributed around the country.
This innovative family of amphiphilic copolymers and terpolymers can form bioactive polymeric nanoparticles to be used in nanomedicine or regenerative medicine, for example for the treatment of skin diseases and osteoarticular regeneration.
Nanomedicine represents one of the most attractive tools to develop new therapies to effectively treat some diseases. However, one of the most relevant limitations of nanoparticles (NPs) drug delivery systems is their poor cellular internalization that significantly reduces the intracellular dosages of drugs to the level below the therapeutic window. In this sense, it is imperative new intelligent-responsive delivery systems to be developed in order to counteract this limitation.
In this context, polymer therapeutics, and more specifically polymer drugs offer the opportunity to obtain bioactive macromolecules with improved pharmacological properties and can be designed with amphiphilic properties that give rise to the formation of micelles or vesicles through self-assembled mechanisms. These polymeric nano-assemblies have several advantages if compared to other traditional treatments. Particularly, the core of the polymeric NPs can be used to encapsulate hydrophobic drugs, improving their bioavailability, decreasing their toxicity and protecting them from degradation processes.
The research networking center is looking to establish license, research or technical cooperation agreements with industrial partners either from Biotech or Pharma sector. These types of cooperation are envisaged in order to enter into pre-clinical collaboration for drug testing and to continue researching until a clinical proof of concept is available.