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A leading Italian public medical research centre committed to healthcare and translational medicine has developed an innovative therapeutic solution based on extracellular vesicles (EV) for treatment of secondary damage effects on ischemic tissues. The medical research centre is looking for industrial partners interested in a licensing agreement or a technical cooperation agreement.
Disorders characterized by ischemia/reperfusion, such as myocardial infarction, stroke, and peripheral vascular disease, continue to be among the most frequent causes of debilitating disease and death. Currently, no broad and effective therapeutic approaches are available most of all due to the very short timeframe (3-6 hours) from stroke symptom onset in which a patient is eligible to receive the tissue plasminogen activator, the only thrombolytic agent able to reduce the secondary effects of ischemia.
The Italian public medical research centre has selected and isolated human mesenchymal stem cells, renowned for their beneficial effects in pathological contexts of acute damage. After a reprogramming process (repCBMSC), the researchers identified a specific set of microRNA (miRNA) able to modulate inflammation in both parental Cord Blood Mesenchymal Stromal Cells - Extracellular vesicles (CBMSC-EV) and Reprogrammed Cord Blood Mesenchymal Stromal Cells - Extracellular vesicles (repCBMSC-EV). This set of miRNA was successfully challenged in a model of brain ischemia, where necrosis was significantly reduced.
The Italian medical research centre is looking for industrial partners interested in a licensing agreement of the technology or in technical agreement for co-development.
The most innovative aspects of this technology are:
- Protective/reparative effect correlated with significant tissue level reduction of apoptotic/inflammatory Tumor necrosis factor (TNFα, 4-fold) and Interferon gamma (INFγ, 3-fold).
- Significant necrosis damage reduction.
Patent pending in Italy. PCT.
Type and tasks of partner sought: industrial partner in the healthcare sector willing to commercialize the technology by specific license agreements or to collaborate with the medical centre to further the development of the technology by a technical agreement.