Summary
- Profile Type
- Technology offer
- POD Reference
- TOSI20250110035
- Term of Validity
- 13 January 2025 - 13 January 2026
- Company's Country
- Slovenia
- Type of partnership
- Investment agreement
- Commercial agreement with technical assistance
- Research and development cooperation agreement
- Targeted Countries
- All countries
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General information
- Short Summary
- Innovative technology for biofilm eradication utilizing rotating magnetic nanorobots to locally degrade and sensitize biofilms, enhancing antibiotic penetration into biofilms and paving the way for more effective therapies is offered under investment agreement, commercial agreement with technical assistance and/or research and development cooperation agreement.
- Full Description
-
Antimicrobial resistance is a critical global public health threat and tough scientific and developmental challenge. Antibiotic-resistant infections cause millions of deaths worldwide. As bacteria develop resistance to antibiotics, the burden on global health intensifies, leading to untreatable infections, prolonged illnesses, and a looming crisis where routine medical procedures and surgeries become perilously risky. Biofilms significantly contribute to the failure of antibiotic therapies, making it imperative to target and eradicate biofilms to combat antibiotic resistance effectively.
Well known Slovenian and French Research Institute in joint collaboration developed a method for biofilm removal by using propelling highly magneto-responsive anisotropic iron oxide nanochains as nanomixers, activated by a classical low frequency magnetic stirrer applying low intensity rotating magnetic fields. An innovative method enables localized disintegration of the biofilm, enhances penetration, and thus improves the efficacy of antibiotic agents. Rotating nanochains effectively disrupt the biofilm and sensitize bacteria to antibiotics. Nanochains activated by a rotating magnetic field in presence of an antibiotic (e.g. methicillin) kill more than 99.99% (= 4 log reduction) of methicillin-resistant biofilm-forming bacteria.
Patent application no. EP23307039.0 was filed in November 2023 and no. PCT/EP2024/083249 in November 2024.
Potential applications for tissues treatment:
• Skin infections: chronic wounds (diabetic foot wounds), traumatic wounds, ulcers
• Mouth: dental substitutes and devices (small tooth glass devices), endodontics, periodontitis
• Tissues/organ infections endocarditis, osteoarticular biofilms
Potential applications for disinfection:
• Reusable medical devices: endoscope and other diagnostic probes, dialysis catheter
• Implantable medical devices: prostheses (orthopedic implants, prosthetic joints, heart valves)
The institute is open for Investment agreement (Joint venture agreement, Licensing IP rights, …), Commercial agreement with technical assistance and/or Research and Development cooperation agreement. - Advantages and Innovations
-
• Biofilm disruption
• Sensitization of bacteria to existing antibiotics
• Biocompatible and non-toxic / safe to mammalian cells - Stage of Development
- Lab tested
- Sustainable Development Goals
- Goal 9: Industry, Innovation and Infrastructure
- Goal 3: Good Health and Well-being
- Goal 6: Clean Water and Sanitation
- IPR status
- IPR applied but not yet granted
Partner Sought
- Expected Role of a Partner
- The institute is looking for a partner, preferably from the health/medical industry, who would like to invest in this innovation development or use it in their products or would like to develop the new product based on it.
- Type and Size of Partner
- SME 11-49
- SME 50 - 249
- Big company
- SME <=10
- R&D Institution
- Other
- University
- Type of partnership
- Investment agreement
- Commercial agreement with technical assistance
- Research and development cooperation agreement
Dissemination
- Technology keywords
- 05005 - Micro- and Nanotechnology
- 05001003 - Inorganic Chemistry
- 06002008 - Microbiology
- Market keywords
- 05010001 - Safety for the elderly
- 05004006 - Surgical instrumentation and equipment
- 05009003 - Animal health
- 05004004 - Medical instruments
- 05003001 - Therapeutic services
- Targeted countries
- All countries
