Summary
- Profile Type
- Technology offer
- POD Reference
- TORO20230503003
- Term of Validity
- 28 August 2023 - 27 August 2025
- Company's Country
- Romania
- Type of partnership
- Research and development cooperation agreement
- Targeted Countries
- All countries
Contact the EEN partner nearest to you for more information.
Find my local partner
General information
- Short Summary
- The invention relates to a method of preparing composite hydrogels based on collagen and silver nanoparticles for the prevention of wound infections. According to the invention, the process consists in the direct reduction of Ag ions, in situ, in the collagen gel, in the presence of reducing agents, such as NaBH4, citric acid, followed by the crosslinking of the hydrogel in the presence of a crosslinking agent such as glutaraldehyde.
- Full Description
- Cutaneous wound healing is a dynamic and complex process involving the extracellular matrix, soluble mediators, and the activation of various cell types. Within a normal healing process, there is a specific transition from the inflammatory phase to tissue regeneration followed by angiogenesis and tissue reorganization. The healing process is slowed down by the existence of a prolonged inflammatory phase and necrotic tissue that favors bacterial adhesion and proliferation, as well as the formation of biofilms. Microbial biofilms are present in approximately 6% of acute wounds and over 90% of chronic wounds. In general, biofilm-producing infections have a slow progression but, once established, are difficult to combat. The management of skin wounds resides in the use of local treatments with the aim of preventing / treating wound infections and rapid and effective tissue regeneration. Wet and dry collagen scaffolds are currently considered one of the most effective strategies in the treatment of acute and chronic skin wounds.
- Advantages and Innovations
-
Biomaterials based on collagen and silver nanoparticles have the advantage of promoting wound healing by:
Providing a skin precursor;
• maintaining optimal humidity and aeration parameters;
• biocompatibility;
• hemostatic properties;
• preventing the formation of microbial biofilms.
The solution proposed by the present invention is the development of advanced (multi)functional hydrogels, based on collagen and inorganic nanoparticles with an antimicrobial effect, to facilitate the healing of acute and chronic skin wounds even in the case of associated infections. The new products could benefit the elderly, paraplegic or immobilized due to other causes, chronic diseases (i.e. diabetes), but also active people with various chronic wounds, burns, chemical skin conditions, surface or deep trauma and mechanical trauma. - Stage of Development
- Lab tested
- Sustainable Development Goals
- Goal 3: Good Health and Well-being
- IPR status
- IPR applied but not yet granted
- IPR notes
- RO134197(A2)
Partner Sought
- Expected Role of a Partner
-
Collaboration requested: (eg license, R&D contract, joint development, Venture Capital, …)
Continuation of research on the basis of a research contract, to increase the Technological Maturity Level from the current level of development (TRL 5) - preclinical level to product on the market (TRL 9). An important stage is the clinical development phase - Type and Size of Partner
- University
- R&D Institution
- SME 11-49
- SME 50 - 249
- Type of partnership
- Research and development cooperation agreement
Dissemination
- Technology keywords
- 06001002 - Clinical Research, Trials
- 06001013 - Medical Technology / Biomedical Engineering
- 06001024 - Medical Biomaterials
- 006001002 - Care and Health Services
- Market keywords
- 05007002 - Pharmaceuticals/fine chemicals
- 05007007 - Other medical/health related (not elsewhere classified)
- Sector Groups Involved
- Health
- Targeted countries
- All countries